28882-53-3

Usage

Uses

Used in Pharmaceutical Industry:
OCHROMYCINONE is used as a novel Stat3 selective inhibitor for its potential role in the development of therapeutic agents targeting various diseases. Its ability to inhibit Stat3 signaling pathways makes it a promising candidate for cancer treatment and other conditions where Stat3 dysregulation is implicated.
Used in Cancer Research:
In the field of cancer research, OCHROMYCINONE is used as a valuable tool to study the role of Stat3 in tumor growth and progression. By inhibiting Stat3 signaling, it helps researchers understand the underlying mechanisms of cancer development and identify potential therapeutic targets.
Used in Drug Development:
OCHROMYCINONE is used as a lead compound in the development of new drugs targeting the Stat3 pathway. Its unique properties and specificity for Stat3 make it an attractive starting point for designing more potent and selective inhibitors with improved pharmacological profiles.
Used in Diagnostic Applications:
OCHROMYCINONE can be employed as a diagnostic agent to detect the activation status of the Stat3 pathway in various disease conditions. Its ability to inhibit Stat3-dependent luciferase reporter activity allows for the development of assays to monitor Stat3 activity in cells and tissues.

InChI:InChI=1/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3/t9-/m0/s1

Upstream product

• 175409-43-5 (S)-Methoxy-phenyl-acetic acid (1S,3S,6S,6aR,12aR,12bS)-8-hydroxy-6-methoxy-3-methyl-7,12-dioxo-1,2,3,4,6,6a,7,12,12a,12b-decahydro-benzo[a]anthracen-1-yl ester 
• 175775-69-6 (1S,3S,6S,6aR,12aR,12bS)-1,8-Dihydroxy-6-methoxy-3-methyl-1,2,3,4,6,6a,12a,12b-octahydro-benzo[a]anthracene-7,12-dione 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 13368-65-5 (3R)-3-methylcyclohexanone 
• 681001-31-0 (R)-5-methyl-1-vinylcyclohex-1-ene 
• 134916-00-0 (4S)-4-benzyl-3-(hex-5-enoyl)-1,3-oxazolidin-2-one 
• 77189-69-6 5-acetoxy-2-bromo-1,4-naphthoquinone 
• 1577-22-6 5-hexenoic acid 
• 949087-72-3 (R)-(3-vinylcyclohex-3-enyl)methyl 4-methylbenzenesulfonamide 
• 949087-71-2 (R)-2-(prop-2-ynyl)hex-5-enyl 4-methylbenzenesulfonate 
• 942513-97-5 (R)-2-(prop-2-ynyl)hex-5-en-1-ol 
• 942513-96-4 (4S)-4-benzyl-3-((R)-2-(prop-2-ynyl)hex-5-enoyl)oxazolidin-2-one 
• 130548-10-6 (+)-rubiginone B2 
• 681001-30-9 (R)-8-hydroxy-3-methyl-1,2,3,4-tetrahydrobenz[a]anthracene-7,12-dione 

Downstream Products

• 130548-10-6 (+)-rubiginone B2 

Relevant academic research and scientific papers

Total synthesis of Angucyclines. Part 18: A short and efficient synthesis of (+)-ochromycinone

A short and highly enantiospecific (seven steps, 99% ee) synthesis of (+)-ochromycinone 2 in 19% overall yield is reported. Key steps are the regioselective Diels-Alder reaction of the juglone derivative 4 with the mixture of dienes 5 and 9 derived from 3-methylcyclohexanone (99% ee) and the photooxidation of 1-deoxyochromycinone 3 to the natural ketone 2. A pronounced concentration dependence of the specific rotation was observed for (+)-ochromycinone 2 in CHCl3.

Angucyclinone antibiotics: Total syntheses of YM-181741, (+)-ochromycinone, (+)-rubiginone B2, (-)-tetrangomycin, and MM-47755

(Chemical Equation Presented) A concise and highly enantioselective route has been developed for the synthesis of angucyclinone-type natural products. Utilizing this strategy, total syntheses of five natural products YM-181741, (+)-ochromycinone, (+)-rubi

Efficient method for synthesis of angucyclinone antibiotics via gold-catalyzed intramolecular [4 + 2] benzannulation: Enantioselective total synthesis of (+)-ochromycinone and (+)-rubiginone B2

An efficient synthetic approach to angucyclinone antibiotics, (+)-ochromycinone and (+)-rubiginone B2, is reported. The key step involves the facile formation of 2,3-dihydrophenantren-4(1H)-one skeleton, an important framework of angucyclinone

Short and efficient enantioselective total synthesis of angucyclinone type antibiotics (+)-rubiginone B2 and (+)-ochromycinone

The enantioselective total synthesis of antibiotics rubiginone B2 and ochromycinone is achieved from enantiopure (S)-5-methoxy-2-(p-tolylsulfinyl)-1,4-naphthoquinone and a racemic vinylcyclohexene through a short sequence involving a tandem Diels-Alder reaction-sulfoxide elimination process with simultaneous kinetic resolution of the racemic diene, followed by controlled aromatization and functional group deprotection.

Total syntheses of the angucyclinone antibiotics (+)-emycin A and (+)-ochromycinone

The first asymmetric synthesis of the angucyclinone antibiotics, emycin A and ochromycinone, is achieved via a short, efficient sequence from 5-hydroxy-1,4-naphthoquinone with the key step being an effective kinetic resolution of a racemic diene in a Diel