288839-59-8Relevant articles and documents
Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9H-pyrrolo [1,2-b][1,3]-benzoxazin-9-one
Huang, Liren,Ellsworth, Edmund L.,Randhawa, Sab,Stier, Michael A.,Huang, Yanting,Bird, Paul,Lebedev, Mikhail,Wu, Kun,Micetich, Ron G.,Domagala, John M.,Singh, Rajeshwar,Colbry, Norm L.
, p. 4061 - 4064 (2007/10/03)
The total synthesis of 6,8-dihydroxy-7-propyl-9H-pyrrolo[1,2- b][1,3]benzoxazin-9-one, a novel antibacterial agent, is described. The key step in the synthesis is achieved via an oxidative cyclization of a phenol to the 2-position of a pyrrole using stoichiometric Pd(OAc)2. This provides a straightforward approach to the tricyclic structure of this previously unreported template and future derivatives. (C) 2000 Elsevier Science Ltd.