288846-86-6

Basic information

• Product Name: D-Mannose-1-C-d
• Synonyms: D-Mannose-1-C-d
• CAS NO: 288846-86-6
• Molecular Formula: C6H12O6
• Molecular Weight: 180.15588
• Product Categories: Carbohydrates & Derivatives, Isotope Labeled Compounds
• Mol File: 288846-86-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-Mannose-1-C-d(CAS DataBase Reference)
• NIST Chemistry Reference: D-Mannose-1-C-d(288846-86-6)
• EPA Substance Registry System: D-Mannose-1-C-d(288846-86-6)

Safety Data

• Hazardous Substances Data: 288846-86-6(Hazardous Substances Data)

Usage

Uses

D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog.

Upstream product

• 5302-80-7 D-<1-14C,1-2H>glucose 6-phosphate 

Relevant articles and documents

PREPARATION OF D-GLUCOSE AND D-GLUCOSE

An enzymic method is presented for the preparation of 14C-labelled and C1-deuterated D-glucose, to be used as a radioactive tracer in metabolic studies dealing with the fate of D-glucose.The procedure takes advantage of the deuteration of 14C-labelled D-fructose 6-phosphate during exposure to phosphomannoisomerase in D2O.It further includes the conversion of the deuterated hexose monophosphates to D-fructose 1,6-bisphosphate, its isolation and hydrolysis to D-fructose 6-phosphate and the partial conversion of the latter ester to D-glucose 6-phosphate, which is then isolated by ion exchange chromatography and hydrolyzed to unesterified D-glucose.The extent of deuteration on the C1 of D-glucose was judged, after conversion to D-glucose 6-phosphate, from the isotopic discrimination in reaction velocity exerted towards the C1-deuterated ester by glucose-6-phosphate dehydrogenase.The degree of isotopic discrimination was virtually identical to that found with D-glucose 6-phosphate prepared from pure D-glucose.