288848-50-0

Upstream product

• 64-17-5 ethanol 
• 80971-95-5 (+/-)-3-amino-3-(4-cyanophenyl)propanoic acid 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 288848-53-3 ethyl 3-(4-cyanophenyl)-3-(pyrrol-1-yl)propionate 
• 288848-57-7 3-(4-cyanophenyl)-2,3-dihydro-1H-pyrrolizin-1-one 
• 517905-92-9 (S)-3-(9-fluorenylmethoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid 
• 517905-92-9 (R)-3-(9-fluorenylmethoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid 
• 501015-22-1 (R)-3-(tert-butoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid 
• 500770-82-1 (S)-3-(tert-butoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid 
• 718596-77-1 (S)-3-amino-3-(4-cyanophenyl)propanoic acid 
• 738606-24-1 (R)-3-amino-3-(4-cyanophenyl)propanoic acid 
• 738606-23-0 ethyl (S)-3-butanoylamino-3-(4-cyanophenyl)propanoate 

Relevant academic research and scientific papers

Synthesis of the enantiomers and N-protected derivatives of 3-amino-3-(4-cyanophenyl)propanoic acid

Racemic ethyl 3-amino-3-(4-cyanophenyl)propanoate was synthesized and the enantiomers separated through enantioselective N-acylation by Candida antarctica lipase A (CAL-A) in neat butyl butanoate. The free amino acid enantiomers were transformed to the Boc and Fmoc-protected derivatives.

New aromatase inhibitors. Synthesis and biological activity of aryl- substituted pyrrolizine and indolizine derivatives

We report herein the design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase. The in vitro b