288856-38-2Relevant academic research and scientific papers
Synthesis and biological activities of fluorinated chalcone derivatives
Nakamura, Chika,Kawasaki, Nobuhide,Miyataka, Hideki,Jayachandran, Ezhuthachan,Kim, In Ho,Kirk, Kenneth L.,Taguchi, Takeo,Takeuchi, Yoshio,Hori, Hitoshi,Satoh, Toshio
, p. 699 - 706 (2002)
We have designed and synthesized new 5-lipoxygenase inhibitors, fluorinated 3,4-dihydroxychalcones, and evaluated their biological activities with respect to antiperoxidation activity and in vitro antitumor activities. All fluorinated chalcones tested showed 5-lipoxygenase inhibition on rat basophilic leukemia-1 (RBL-1) cells and inhibitory action on Fe3+-ADP induced NADPH-dependent lipid peroxidation in rat liver microsomes. The potencies were comparable or better to that of the lead 3,4-dihydroxychalcone. 6-Fluoro-3,4-dihydroxy-2′,4′-dimethoxy chalcone (7) was the most effective compound in the in vitro assay using a human cancer cell line panel (HCC panel) consisting of 39 systems.
