289-85-0

Upstream product

• 7774-74-5 Thiophene-2-thiol 
• 73122-56-2 2-chloro-5,6-dihydro-4H-1,3-thiazine hydrochloride 
• 70-23-5 ethyl Bromopyruvate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 50918-06-4 1-chloro-3-methoxymethoxy-propan-2-one 

Relevant academic research and scientific papers

Thiazines and thiazoles as agents for protecting materials

The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial materials.

Tricyclic benzodiazepines as vasopressin receptor antagonists

The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

Six-membered hetero "N" compounds

Novel six-membered hetero "N" compounds having antibiotic activity, represented by the formula: STR1 where X=S, O, CH2, or Se Y=OH, NH2, NHCOR9, or SH R1,R2,R3,R4,R5,R6,R7 (which may be identical or different)=H, alkyl, or aryl R9 =a β-lactam active side chain; computer models for evaluating such compounds and processes for preparing them.

β-Lactam antibiotics, a process for their prepaeration and their use in pharmaceutical compositions

The present invention provides the antibacterial agents of the formula (II): STR1 wherein R1 is a group such that CO2 R1 is a carboxylic acid group or a salt thereof or is a group of the formula CO2 R11 wherein R11 is a group such that CO2 R11 is an ester group, R2 is a hydrogen atom or a lower alkyl group; R3 is a hydrogen atom or a lower alkyl group; and R4 is a NH. COn R6 group where R6 is a lower alkyl group, a phenyl group or a phenyl group substituted by one or two halogen atoms, lower alkyl or lower alkoxyl groups; and n is 1 or 2. A process for their preparation and their use in pharmaceutical compositions is also described.

Cephalosporin compounds

Novel 7-azido-3-cephem compounds are prepared via α-amino-phosphonoacetate esters. The cephem compounds are intermediates for the preparation of novel and known useful antibiotic cephalosporins.