289046-83-9

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 123-72-8 butyraldehyde 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 289046-84-0 (1R,2S)-phenyl-2-(1-propyl-3-trimethylsilanylmethylbut-3-enylamino)ethanol 
• 408351-28-0 [2S,2(1R,3E)]-2-phenyl-2-[[1-propyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol 
• 1071226-92-0 (2S)-2-((1R)-4-methoxy-1-propylbut-3-enylamino)-2-phenylethanol 

Relevant academic research and scientific papers

Regio- and diastereochemical aspects of the additions of Li or Zn derivatives of methoxypropene to oxazolidines derived from phenylglycinol

Diastereoselective additions of methoxypropene-derived lithium and zinc reagents to oxazolidines are investigated. The lithium allylic carbanion reacts with oxazolidines to afford mainly the β-amino alcohols with an enol ether function (γ-adduct) and the

Asymmetric syntheses of new functionalized β-amino alcohols via diastereoselective addition of organometallic reagents onto oxazolidines

Diastereoselective reactions between (S)-phenylglycinol-derived oxazolidines and two unsaturated organolithium reagents afforded chiral β-amino alcohols having vinyl and alkynylsilane moieties. When the same reactions were performed in the presence of titanium isopropoxide, a dramatic change of regioselectivity was observed, from the α- to the γ-position, thus producing β-amino alcohols with allyl or allenylsilane functions. A rationalization of the observed diastereoselectivity was suggested for each case.