28910-99-8

Basic information

• Product Name: NitrazolaM
• Synonyms: NitrazolaM;1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine;1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;Nitrazolam ada@tuskwei.com whatsapp
• CAS NO: 28910-99-8
• Molecular Formula: C₁₇H₁₃N₅O₂
• Molecular Weight: 319.31742
• Product Categories: Nitrazolam ada@tuskwei.com whatsapp;8618031153937
• Mol File: 28910-99-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NitrazolaM(CAS DataBase Reference)
• NIST Chemistry Reference: NitrazolaM(28910-99-8)
• EPA Substance Registry System: NitrazolaM(28910-99-8)

Safety Data

• Hazardous Substances Data: 28910-99-8(Hazardous Substances Data)

Usage

Description

Nitrazolam is classified as a novel benzodiazepine, although its synthesis and activity have been previously described in the literature. Benzodiazepines are central nervous system depressants. Novel benzodiazepines, often pirated from early drug discovery or pharmaceutical studies, have appeared on the novel and illicit drug markets in recent years. These substances have caused adverse events, including deaths, as described in the literature. Nitrazolam is structurally similar to traditional benzodiazepines nitrazepam and alprazolam, Schedule IV substances in the United States, as well as the novel benzodiazepines flunitrazolam and clonazelam. ?

Synthetic route

7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (35628-44-5) + butan-1-ol (71-36-3) → 1-methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (28910-99-8)

Conditions	Yield
In water

Upstream product

• 35628-44-5 7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione 
• 71-36-3 butan-1-ol 

Relevant articles and documents

Benzodiazepine derivatives

Benzodiazepine derivatives of the general formula STR1 where R1 is hydrogen or a hydrocarbon residue of 1-8 carbon atoms, R2 is hydrogen or lower alkyl and rings A and B are unsubstituted or substituted by nitro, trifluoromethyl, halogen, lower alkyl or lower alkoxy, the nitrogen atom in the 5-position being unsubstituted or substituted by an oxygen atom, useful as muscle relaxants, anticonvulsants, sedatives and tranquilizing agents, and processes for production thereof. Also provided are novel intermediates of the general formula STR2 where R2 has the above meaning, rings A and B are unsubstituted or substituted as above and the nitrogen atom in the 4-position is unsubstituted or substituted by an oxygen atom.

Animal feed and process

An animal feed comprising a compound of the group consisting of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula: STR1 WHEREIN R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, phenyl, benzyl and -COOR' in which R' is alkyl of 1 to 4 carbon atoms, inclusive; wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, R4 and R5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino in which the carbon chain moieties are of 1 to 3 carbon atom, inclusive and their pharmacologically acceptable acid addition salts in combination with a nutrient feed. A process for obtaining increased productivity in meat producing, milk producing, and egg laying animals by feeding the aforementioned compounds in combination with nutrient feeds.