28912-70-1

Upstream product

• 504-29-0 2-aminopyridine 
• 1986-08-9 S-chloro-N-phenylisothiocarbamoyl chloride 
• 28912-69-8 N-pyridin-2-yl-S-trichloromethyl-thiohydroxylamine 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 

Relevant academic research and scientific papers

Visible light promoted formation of N─S bond by photocatalyst Eosin Y

A novel efficient protocol for the synthesis of 5-imino-1,2,4-thiadiazole motif in open air and visible light has been reported. The reaction involves Eosin Y as photocatalyst which is a cost-effective organic dye. The designed protocol represents a novel, mild, metal free, green strategy for the construction of 1,2,4-thiadiazole nucleus by intramolecular cyclization via N─S bond formation. The reaction has been carried out under visible light exposure in ethanol: water (4:1) mixture using 2-aminopyridine and isocyanate as reactants.

Electrochemical Synthesis of 1,2,4-Thiadiazoles through Intermolecular Dehydrogenative S-N Coupling

An electrochemical intermolecular dehydrogenative coupling reaction of isothiocyanates with 2-aminopyridines/amidines was developed. Using n-Bu4NI as the catalyst and electrolyte, 1,2,4-thiadiazoles and pyrido-fused 1,2,4-thiadiazoles were readily accessed with good to excellent efficiency under the undivided electrolysis conditions. This electrochemical approach obviates the use of external oxidants and transition-metal catalysts. (Figure presented.).

Copper-Catalyzed Aerobic Oxidative [3+2] Annulation for the Synthesis of 5-Amino/Imino-Substituted 1,2,4-Thiadiazoles through C-N/N-S Bond Formation

A copper-catalyzed aerobic oxidative annulation reaction of 2-aminopyridine/amidine with isothiocyanate has been reported. This strategy involving C-N/N-S bond formations provides various 5-amino/imino-substituted 1,2,4-thiadiazole derivatives under a Cu/O2 catalytic system. This method has demonstrated high reactivity, mild reaction conditions, and a broad substrate scope. Furthermore, the synthetic utilities of the approach are demonstrated by further modifications.

I2-Catalyzed Oxidative N-S Bond Formation: Metal-Free Regiospecific Synthesis of N-Fused and 3,4-Disubstituted 5-Imino-1,2,4-thiadiazoles

A novel and expeditious approach for the synthesis of N-fused and 3,4-disubstituted 5-imino-1,2,4-thiadiazole derivatives has been achieved through the molecular iodine-catalyzed oxidative cyclization of 2-aminopyridine/amidine and isothiocyanate via N-S

Synthesis of Ring-Fused 1,2,4-Thiadiazoles

1-Chloro-1-phenyliminomethanesulfenyl chloride readily yields derivatives of the 3H-1,2,4-thiadiazolo-pyridine, -pyrazine, -pyrimidine and -benzothiazole as well as the 3H-thiazolo- and 3H-1,3,4-thiadiazolo-thiadi