28919-19-9Relevant academic research and scientific papers
Direct isocyanomethylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen with phenylthiomethyl isocyanide carbanion
Makosza,Kinowski,Ostrowski
, p. 1215 - 1217 (2007/10/02)
Reaction of nitroarenes with phenylthiomethyl isocyanide in the presence of potassium tert-butoxide results in the introduction of the isocyanomethyl substituent into positions ortho or para to the nitro group. The products of the reaction when subjected to mild hydrolysis can be converted into nitrobenzylic amines or their formyl derivatives.
CONVENIENT SYNTHESIS OF 2-THIONAPHTHYLMETHYL ISOCYANIDE: A USEFUL REAGENT FOR METHYL ISOCYANIDE TRANSFER
Ranganathan, S.,Singh, W. P.
, p. 1435 - 1436 (2007/10/02)
The crystalline 2-thionaphthylmethyl isocyanide (1), prepared from the novel N-(formamidomethyl)-N-benzyl morpholinium iodide (2), via transfer of elements of CH2NHCHO, is totally devoid of pervasive odour.The cyclo-addition of the conjugate base of (1) to nitriles followed by desulfurization, under very mild conditions, provides an attractive route to imidazoles.
A NEW GENERAL METHOD OF α-AMIDO-ALKYLATION
Morton, J.,Rahim, A.,Walker, E. R. H.
, p. 4123 - 4126 (2007/10/02)
N-(1-p-Toluenesulphonyl-alkyl) amides, which are readily prepared from an aldehyde, an amide and sodium p-toluenesulphinate, are versatile α-amido-alkylating agents for sulphur nitrogen and carbon nucleophiles.
