2894-51-1

Basic information

• Product Name: 2-Amino-4'-chlorobenzophenone
• Synonyms: 2-AMINO-4'-CHLOROBENZOPHENONE;(2-AMINO-PHENYL)-(4-CHLORO-PHENYL)-METHANONE;2-AMINO-4''-CHLOROBENZOPHENONE 96+%;2-Amino-4'-chlorobenzophenone;(2-azanylphenyl)-(4-chlorophenyl)methanone;2-AMino-4'-chlorobenzophenone, 98.0%(GC&T;(2-Aminophenyl);2-Amino-4'-chlorobenzophenone, 98.5%
• CAS NO: 2894-51-1
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• EINECS: 220-770-3
• Product Categories: API intermediates
• Mol File: 2894-51-1.mol
• Article Data: 36

Chemical Properties

• Melting Point: 103°C
• Boiling Point: 419.8 °C at 760 mmHg
• Flash Point: 207.7 °C
• Appearance: /
• Density: 1.274 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Chloroform
• PKA: -0.35±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4'-chlorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4'-chlorobenzophenone(2894-51-1)
• EPA Substance Registry System: 2-Amino-4'-chlorobenzophenone(2894-51-1)

Safety Data

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• RTECS: XZ1900000
• Hazardous Substances Data: 2894-51-1(Hazardous Substances Data)

Usage

Uses

2-Amino-4-chlorobenzophenone is used in the synthesis of antiplasmodial agents.

Upstream product

• 38046-68-3 3-(4-chlorophenyl)benzo[c]isoxazole 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 108-90-7 chlorobenzene 
• 5100-23-2 2-isocyanatobenzoyl chloride 
• 7664-93-9 sulfuric acid 
• 2998-99-4 (E)-(4-chlorophenyl)(phenyl)methanone oxime 
• 7647-01-0 hydrogenchloride 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 10026-13-8 phosphorus pentachloride 
• 2998-98-3 (Z)-(4-chlorophenyl)(phenyl)methanone oxime 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 98018-68-9 2-(4-chlorobenzyl)phenylamine 
• 78281-62-6 2-amino-3-(4-chlorobenzoyl)-α-(phenylthio)benzeneacetamide 
• 79039-73-9 7-(4-chlorophenyl)-5,6-dihydrobenzacridine 
• 138366-02-6 2-bromo-2'-(4-chlorobenzoyl)acetanilide 
• 500870-77-9 2-N-(4-methylsulfonylbenzoyl)-amide-4'-chloro-benzophenone 
• 500870-78-0 2-N-(4-aminosulfonylbenzoyl)-amide-4'-chloro-benzophenone 
• 101894-87-5 2-aminophenyl-α,α-di(p-anisyl) methanol 
• 65246-99-3 (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)methanone 
• 35059-36-0 4-(4-chloro-phenyl)-1,4-dihydro-benzo[d][1,3]oxazine-2-thione 
• 35001-94-6 4-(4-chloro-phenyl)-2-methylsulfanyl-4H-benzo[d][1,3]thiazine 
• 35059-35-9 4-(4-chloro-phenyl)-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 61085-31-2 7-(4-chlorobenzoyl)-3-methylthioindolin-2-one 
• 827576-99-8 N-[4-({[2-(4-chlorobenzoyl)phenyl]amino}sulfonyl)phenyl]acetamide 
• 1253396-17-6 N-[2-(4-chlorobenzoyl)phenyl]formamide 

Relevant articles and documents

THERAPEUTIC COMPOSITION OF CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USAGE

The present application is directed to a therapeutic composition, comprising two precursor compounds (monomers) that are suitable for assembly via two or more reversible covalent bonds. The monomers are polyfunctionalized molecules comprising a bioorthogo

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.