28944-98-1Relevant academic research and scientific papers
Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters
Chen, Hao,He, Maomao,Wang, Yaya,Zhai, Linhui,Cui, Yongbo,Li, Yangyan,Lee, Yan,Zhou, Haibing,Hong, Xuechuan,Deng, Zixin
, p. 2723 - 2726 (2011/11/06)
Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi
Stereochemical issues related to the synthesis and reactivity of pyrazino [2',1'-5,1] pyrrolo[2,3-b]indole- 1,4-diones
Caballero, Esmeralda,Avendano, Carmen,Menendez, J. Carlos
, p. 967 - 981 (2007/10/03)
The cyclization of all four diastereoisomers of cyclo-(Trp-Ala) to the corresponding 3,5a,6,10b,11,11a-hexahydro-2H-pyrazino[2',1'-5,1]pyrrolo[2,3- b]indoles is studied from the stereochemical point of view. Epimerization of the tryptophan stereocenter du
Dehydrogenation of Indolines to Indoles via Azasulphonium Salts or N-Chloramines
Kawase, Masami,Miyake, Yuko,Kikugawa, Yasuo
, p. 1401 - 1404 (2007/10/02)
The dehydrogenation of indolines to indoles without using mineral oxidising reagents is described.The conversion was achieved via either azasulphonium salts or N-chloramines, the former route involving milder conditions but a more complex procedure.
A NEW DEHYDROGENATION REACTION OF INDOLINES TO INDOLES VIA AZASULFONIUM SALTS
Kikugawa, Yasuo,Kawase, Masami
, p. 445 - 446 (2007/10/02)
Indolines (1) have been converted to the corresponding azasulfonium salts (2) and the subsequent intramolecular base catalyzed abstraction of the hydrogen at C-2 gave indoles (4) in good yields.
