28946-00-1Relevant academic research and scientific papers
Chemotherapeutic nitroheterocycles. 18. 2 (5 Nitro 2 imidazolylmethylene) 1 indanones, 1 tetralones, and acetophenones substituted by aminoalkoxy groups
Rufer,Kessler,Schroeder
, p. 253 - 258 (1975)
2 (5 Nitro 2 imidazolylmethylene) 1 indanones; 1 tetralones, and acetophenones with aminoalkoxy substituents, groups and related compounds, were synthesized and their antimicrobial activities were evaluated. Some of these compounds surprisingly exhibited a broad antibacterial spectrum including Proteus species and Pseudomonas aeruginosa. High antitrichomonal activities were also observed in vitro minimum inhibitory concentration of 0.0004 μg/ml) and six compounds displayed in vivo activity against Trichomonas vaginalis in mice comparable to that of metronidazole.
