289472-78-2 Usage
Uses
Used in Pharmaceutical Industry:
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide is used as a potential pharmaceutical agent for its unique structural features and functional groups. The presence of an amino group, a hydroxyl group, and a phenyl group, along with its chiral nature, may allow it to bind to specific biological targets, making it a candidate for the development of new drugs.
Used in Drug Design and Development:
In the field of drug design and development, N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide can be utilized as a starting point for the synthesis of novel compounds with potential therapeutic effects. Its structural features and functional groups can be further modified to optimize its binding affinity and selectivity towards specific biological targets, leading to the discovery of new drugs with improved efficacy and safety profiles.
Used in Research and Development:
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide serves as a valuable compound for research and development in the field of chemistry and biology. Its unique structure and functional groups provide opportunities for studying its interactions with biological systems, as well as its potential applications in various therapeutic areas. Further research is needed to fully understand its properties and explore its potential uses in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 289472-78-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,9,4,7 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 289472-78:
(8*2)+(7*8)+(6*9)+(5*4)+(4*7)+(3*2)+(2*7)+(1*8)=202
202 % 10 = 2
So 289472-78-2 is a valid CAS Registry Number.
289472-78-2Relevant academic research and scientific papers
Degradation pathways of a peptide boronic acid derivative, 2-Pyz-(CO)-Phe-Leu-B(OH)2
Wu, Sara,Waugh, Wanda,Stella, Valentino J.
, p. 758 - 765 (2007/10/03)
The peptide boronic acid derivative 2-Pyz-(CO)-Phe-Leu-B(OH)2 is a potent inhibitor of 20S proteasome and a proposed anticancer agent. During preformulation studies, the compound presented erratic stability behavior. Efforts were made to isolate and identify the degradation products, thereby helping to identify possible mechanisms for the degradation. The reaction of 2-Pyz-(CO)-Phe-Leu-B(OH)2 with hydrogen peroxide not only provided a convenient way to isolate the initial degradation products seen from hydrolysis in aqueous buffers but also showed that the major, initial degradation pathway was probably oxidative in nature. The isolated degradation products were characterized by nuclear magnetic resonance spectroscopy, mass spectrometry, and optical rotation dispersion. In the presence of hydrogen peroxide, the boronic acid group was cleaved from 2-Pyz-(CO)-Phe-Leu-B(OH)2 to give an alcohol with an apparent retention of the original stereochemistry. Subsequent isomerization and further hydrolysis were then seen. Surprisingly, added ascorbate and EDTA accelerated rather than inhibited degradation. Degradation of 2-Pyz-(CO)-Phe-Leu-B(OH)2 under acidic and basic conditions seemed to be mediated by an initial oxidative degradation pathway similar to that seen with the peroxide. (C) 2000 Wiley-Liss, Inc.
