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289472-78-2

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289472-78-2 Usage

General Description

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide is a chemical compound with the molecular formula C24H31N5O3. It is a pyrazine-2-carboxamide derivative that contains an amino group, a hydroxyl group, and a phenyl group. N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide is a chiral molecule with both R and S stereocenters. It may have potential pharmaceutical applications due to its structural features and functional groups, which could make it suitable for binding to specific biological targets and exerting biological effects. Further research is needed to fully understand the properties and potential uses of this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 289472-78-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,9,4,7 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 289472-78:
(8*2)+(7*8)+(6*9)+(5*4)+(4*7)+(3*2)+(2*7)+(1*8)=202
202 % 10 = 2
So 289472-78-2 is a valid CAS Registry Number.

289472-78-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

1.2 Other means of identification

Product number -
Other names (R)-Hydroxy Des(boric Acid) Bortezomib

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:289472-78-2 SDS

289472-78-2Upstream product

289472-78-2Relevant articles and documents

Degradation pathways of a peptide boronic acid derivative, 2-Pyz-(CO)-Phe-Leu-B(OH)2

Wu, Sara,Waugh, Wanda,Stella, Valentino J.

, p. 758 - 765 (2007/10/03)

The peptide boronic acid derivative 2-Pyz-(CO)-Phe-Leu-B(OH)2 is a potent inhibitor of 20S proteasome and a proposed anticancer agent. During preformulation studies, the compound presented erratic stability behavior. Efforts were made to isolate and identify the degradation products, thereby helping to identify possible mechanisms for the degradation. The reaction of 2-Pyz-(CO)-Phe-Leu-B(OH)2 with hydrogen peroxide not only provided a convenient way to isolate the initial degradation products seen from hydrolysis in aqueous buffers but also showed that the major, initial degradation pathway was probably oxidative in nature. The isolated degradation products were characterized by nuclear magnetic resonance spectroscopy, mass spectrometry, and optical rotation dispersion. In the presence of hydrogen peroxide, the boronic acid group was cleaved from 2-Pyz-(CO)-Phe-Leu-B(OH)2 to give an alcohol with an apparent retention of the original stereochemistry. Subsequent isomerization and further hydrolysis were then seen. Surprisingly, added ascorbate and EDTA accelerated rather than inhibited degradation. Degradation of 2-Pyz-(CO)-Phe-Leu-B(OH)2 under acidic and basic conditions seemed to be mediated by an initial oxidative degradation pathway similar to that seen with the peroxide. (C) 2000 Wiley-Liss, Inc.

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