289476-22-8

Usage

Uses

Used in Pharmaceutical Industry:
(1-PHENYL-ETHYL)-PYRIDIN-4-YLMETHYL-AMINE is used as a potential candidate for the development of new drugs targeting the central nervous system due to its structural features as a derivative of phenethylamine and pyridine. Its specific biological activity and therapeutic potential would need to be explored through further research and clinical trials.

Upstream product

• 890415-66-4 (+)-1-[N-(α-methylbenzylamino)]-1-(4-pyridyl)-methyl-phenylmethylphosphine oxide 
• 890415-65-3 [(S)-((R)-tert-Butyl-phenyl-phosphinoyl)-pyridin-4-yl-methyl]-((R)-1-phenyl-ethyl)-amine 
• 890415-64-2 (R)-(+)-1-[N-(α-methylbenzylamino)]-1-(4-pyridyl)-(S)-methyldiphenylphosphine oxide 
• 1215021-09-2 1[(S)-α-(methylbenzylamino)]-1-(R)-(4-pyridyl)-methyl-H-phosphinic acid 

Downstream Products

• 1215021-12-7 N-(4-pyridylmethyl)-(S)-α-methylbenzylamine oxalate 

Relevant academic research and scientific papers

Aminophosphinic acids in a pyridine series, Part 2: Synthesis of 2-, 3-, and 4-pyridyl derivatives of 1-(Benzylamino)-methyl-H-phosphinic Acids

New 2-pyridyl, 3-pyridyl, and 4-pyridyl derivatives of 1-[N-(benzyl)amino]- methyl-H-phosphinic acid were prepared by the addition of bis(trimethylsilyl) phosphonite to the corresponding imines and subsequent methanolysis of the addition products. Treatment of the 2-pyridyl- and 1-(4-pyridyl)-1-(benzylamino) -methyl-H-phosphinic acids with aqueous mineral acids leads to cleavage and formation of the corresponding secondary amines and phosphorous acid (H3PO3).

Aminophosphine oxides in a pyridine series. Studies on the cleavage of pyridine-2- and pyridine-4-yl-(N-benzylamino)-methyldiphenylphosphine oxides in acidic solutions

The synthesis and reactions of 1-(N-benzylamino)-1-(2-pyridyl)- and 1-(N-benzylamino)-1-(4-pyridyl)-methyldiphenylphosphine oxides are described. It was found that these compounds were exceptionally easy to cleave in aqueous sulfuric acid solutions to form diphenylphosphinic acid and the corresponding N-(pyridylmethyl)-benzylamines. The structure of a single diastereoisomer, that is, the (R)-(+)-1-[N-(α-methylbenzylamino)]-1-(4-pyridyl)-(S)-methyldiphen ylphosphine oxide was determined by X-ray crystallography. The acidic alcoholysis of the selected model chiral pyridine aminophosphine oxides was investigated by means of 31P NMR spectroscopy. The cleavage kinetics were also studied. On the basis of the obtained results, a mechanism of the cleavage was formulated.