289483-80-3

Basic information

• Product Name: 4-METHYL-7-NITRO-1H-INDOLE
• Synonyms: 4-METHYL-7-NITRO-1H-INDOLE;1H-Indole, 4-Methyl-7-nitro-
• CAS NO: 289483-80-3
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Mol File: 289483-80-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 384.382 °C at 760 mmHg
• Flash Point: 186.268 °C
• Appearance: /
• Density: 1.355
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-METHYL-7-NITRO-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-7-NITRO-1H-INDOLE(289483-80-3)
• EPA Substance Registry System: 4-METHYL-7-NITRO-1H-INDOLE(289483-80-3)

Safety Data

• Hazardous Substances Data: 289483-80-3(Hazardous Substances Data)

Usage

General Description

4-Methyl-7-nitro-1H-indole is a chemical compound with the molecular formula C9H8N2O2. It is classified as an organic nitro compound and belongs to the class of indoles, which are aromatic heterocyclic organic compounds. This chemical is a yellow to orange crystalline solid with a melting point of 183-185°C. It is mainly used as a building block in organic synthesis and pharmaceutical research. Its nitro group makes it useful for the synthesis of various pharmaceuticals and dyes. Additionally, 4-Methyl-7-nitro-1H-indole has potential applications in the field of material science and as a reagent in various chemical reactions.

InChI:InChI=1/C9H8N2O2/c1-6-2-3-8(11(12)13)9-7(6)4-5-10-9/h2-5,10H,1H3

Downstream Products

• 289483-82-5 3-Cyano-4-methyl-7-nitro-1H-indole 
• 289483-81-4 3-Formyl-4-methyl-7-nitro-1H-indole 
• 289483-87-0 7-Amino-3-cyano-4-methyl-1H-indole 

Relevant articles and documents

Integrin expression inhibitors

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

INTEGRIN EXPRESSION INHIBITORS

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, -CH=CH- or - (CR4bR5b)mb- (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or -CO-NH-; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.