289498-45-9Relevant articles and documents
Ru(II)-catalyzed β-carboline directed C-H arylation and isolation of its cycloruthenated intermediates
Rajkumar, Subramani,Karthik, Shanmugam,Gandhi, Thirumanavelan
, p. 5532 - 5545 (2015/06/16)
A Ru(II)-catalyzed C-H arylation approach has been developed utilizing β-carboline alkaloids as the directing group. Selective formations of diarylated products from moderate to excellent yields were accomplished. Broad substrate scope with excellent functional group tolerance for C1-phenyl/thienyl/PAHs-β-carbolines was demonstrated. X-ray crystal structure of cycloruthenated complex 2cr and no arylation reaction with model substrate 13 strongly suggests that N2 is the directing group than N9 in C1-aryl-β-carbolines. Catalytic properties and stability of the cycloruthenated complexes have been explored. Library of biologically relevant new β-carboline derivatives and isolation of its cycloruthenated intermediates are the highlights of this work.
Synthesis of 2-acyltetrahydro-β-carbolines by an intramolecular α- amidoalkylation reaction
Venkov, Atanas P.,Boyadjieva, Atanaska K.
, p. 487 - 494 (2007/10/03)
2-Acyltetrahydro-β-carbolines 7 have been obtained by cyclization of adducts 5 from imines 3 of tryptamine 1 and aldehydes 2 with acyl chlorides 4 as a result of an intramolecular α-amidoalkylation reaction in the presence of bases as N,N-dimethylaniline or Et3N.
