289499-45-2 Usage
Uses
Used in Anticancer Applications:
Canertinib dihydrochloride is used as an anti-cancer agent for its ability to suppress the proliferation of various cancer cell types. It is effective in inhibiting the growth of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), inducing dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and reducing the proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Additionally, it demonstrates anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.
Used in Pharmaceutical Industry:
Canertinib dihydrochloride is used as a water-soluble, EGFR, HER2, and ErbB-4 tyrosine kinase inhibitor for the development of targeted cancer therapies. Its potent inhibition of these kinases makes it a valuable compound in the creation of drugs aimed at treating various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 289499-45-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,9,4,9 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 289499-45:
(8*2)+(7*8)+(6*9)+(5*4)+(4*9)+(3*9)+(2*4)+(1*5)=222
222 % 10 = 2
So 289499-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
