289503-25-9

Upstream product

• 189265-99-4 6-bromo-1-(4-methylphenylsulfonyl)-1H-indole 

Downstream Products

• 289503-26-0 N-tosyl-6-bromo-3-indolylboronic acid 
• 289503-27-1 2-amino-4-(N-tosyl-6'-bromo-3'-indolyl)pyrimidine 

Relevant academic research and scientific papers

Synthesis of indolylpyrimidines via cross-coupling of indolylboronic acid with chloropyrimidines facile synthesis of meridianin D

Palladium catalyzed cross-coupling reaction of 3-indolylboronic acid with 2,4-dichloropyrimidines proceeded regioselectively to yield indolyl-or bis(indolyl)pyrimidines in high yield, depending on the projection of 3indolylboronic acid. The marine indole alkaloid meridianin D and an analogue were synthesised via the palladium catalyzed cross-coupling reaction as a key step.