28957-78-0

Upstream product

• 3772-55-2 dehydroabietinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 514-10-3 (?)-abietic acid 
• 1740-19-8 dehydroabietic acid 

Downstream Products

• 67119-95-3 (5S,10S)-abieta-9,11,13-trien-14-ol 
• 514-62-5 ferruginol 

Relevant academic research and scientific papers

Syntheses of taiwaniaquinone F and taiwaniaquinol A via an unusual remote C-H functionalization

A protecting-group-free route to (-)-taiwaniaquinone F based on a ring contraction and subsequent aromatic oxidation of a sugiol derivative is reported. In addition, the first synthesis of (+)-taiwaniaquinol A is reported via short time exposure of (-)-taiwaniaquinone F to sunlight triggering a remote C-H functionalization. The hypothesis that the biogenesis of some methylenedioxy bridged natural products could proceed via similar nonenzymatic mechanisms is presented.

Efficient ortho-oxidation of phenol and synthesis of anti-MRSA and anti-VRE compound abietaquinone methide from dehydroabietic acid

A quinone methide diterpene: abietaquinone methide, which possesses potent anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-vancomycin- resistant Enterococcus (VRE) activities, was synthesized via efficiently ortho-oxidation of ferruginol derived from industrially available dehydroabietic acid. ortho-Oxidation of phenols was developed to give mono esters of catechols using a stable diacyl peroxide, bis(4-chlorobenzoyl) peroxide (m-chlorobenzoyl peroxide: mCBPO) which was synthesized from meta-chlorobenzoic acid. Efficient one pot ortho-oxidation reaction of phenol with an adduct of meta-chloroperbenzoic acid (mCPBA) with dicyclohexylcarbodiimide (DCC) was also reported.

A dehydrogenation fir acid derivative and its preparation method and application (by machine translation)

The application relates to a dehydrogenation fir acid derivatives, the dehydroabietic acid derivatives preparation method and the dehydroabietic acid derivatives in the preparation of an anticancer drug. The application will be dehydroabietic acid carboxyl reduction dioxiding hydroxy, get the alcoholic hydroxy with anticancer activity of dehydroabietic acid derivatives. Then, to the alcoholic hydroxyl group as the starting compound dehydroabietic acid derivatives, the introduction of alkyl, acyl and aromatic sulfonyl and further improve the dehydroabietic acid derivatives of the anti-cancer activity. Beneficial effect of the application is characterized in that the elastomeric natural products, the raw materials used are non-toxic to the patient, and raw materials are easy, the price is cheap, simple method of synthesis of compounds, synthetic compounds obtainable by anticancer effect. (by machine translation)

Studies with plant-cell cultures of the Chinese herbal plant, Tripterygium wilfordii. Isolation and characterization of diterpenes

A detailed analysis of the established cell-culture line (coded as TRP4a) of the important Chinese herbal plant, Tripterygium wilfordii, in terms of diterpene production, is presented. In this study, 28 diterpenes have been isolated and characterized. Of these, 26 were isolated for the first time from the TRP4a cell line, 8 were novel compounds. From an analysis of the diterpenes obtained, a biosynthetic pathway of the pharmacologically interesting triepoxide, tripdiolide 29, is proposed.