289631-40-9Relevant academic research and scientific papers
Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 6. Synthesis of a key intermediate via a highly efficient macrolactonization of a computer-aid designed seco-acid
Matsushima, Tomohiro,Nakajima, Noriyuki,Zheng, Bao-Zhong,Yonemitsu, Osamu
, p. 855 - 860 (2007/10/03)
A stereoselective synthesis is described of the 18-membered lactone (2) via an efficient macrolactonization of the conformation-controlled seco-acid (3); this was designed with the aid of molecular mechanics (MM)-calculation and synthesized by coupling between the C1 - C12 (4) and C13 - C23 (5) fragments.
