289634-11-3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 138403-43-7 2-(4-nitrobenzyl)-1,4,7,10,13,16-hexaazacyclooctadecane 

Downstream Products

• 138379-37-0 p-aminobenzyl-1,4,7,10,13,16-hexaazacarboxylmethyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 360779-33-5 [2-(4-amino-benzyl)-4,7,10,13,16-pentakis-tert-butoxycarbonylmethyl-1,4,7,10,13,16hexaaza-cyclooctadec-1-yl]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

225Ac-HEHA and related compounds, methods of synthesis and methods of use

The present invention provides an α-particle-emitting radioisotope chelation complex comprising225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N′″,N″″,N′″″-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional225Ac-HEHA. The bifunctional HEHA and the bifunctional225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from225Ac, a method of decontaminating a person who has been externally contaminated with225Ac, and a method of detoxifying a person who has internalized225Ac.

Bifunctional chelating agent

The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO2, —NH2, —NCS, —NHCOCH2-Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or —NHCO(CH2)?m ?-Q where Q is an

Synthesis of a novel bifunctional chelating agent for actinium complexation

A novel bifunctional chelating agent for actinium was synthesized in eight steps. Bimolecular cyclization between an iminodiester and a polyamine was achieved through the action of a molar equivalent of sodium methoxide. (C) 2000 Elsevier Science Ltd.