289635-75-2

Upstream product

• 289635-74-1 O-benzyl-(E)-hexadec-3-en-1-ol 
• 143-15-7 1-dodecylbromide 
• 88109-68-6 n-3-hexadecyn-1-ol 
• 128999-42-8 (E)-hexadec-3-en-1-ol 

Downstream Products

• 289635-84-3 (3R,4R)-1-O-benzyl-3,4-O-isopropylidenehexadecane-1,3,4-triol 

Relevant academic research and scientific papers

Synthesis of (4R,12S,15S,16S,19R,20R,34S)-muricatetrocin and (4R,12R,15S,16S,19R,20R,34S)-muricatetrocin, two potent inhibitors of mitochondrial complex I

(4R,12S,15S,16S,19R,20R,34S)-Muricatetrocin (1) and (4R,12R,15S,16S,19R,20R,34S)-muricatetrocin (2) were synthesized by a modular synthetic strategy. Both compounds act as potent inhibitors of mitochondrial complex I. Compound 1 showed analytical data in agreement with howiicin E and a fit with the data for muricatetrocin A if one reassigns the reported 13C signals for C(13) and C(14). Compound 2 matched muricatetrocin B in respect to all NMR data. However, a lower optical rotation was found for 2 ([α](D)/28 = +6.7) than was reported for the natural product ([α](D)/25 = +15.0).