289677-28-7Relevant academic research and scientific papers
Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them
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Page/Page column 15, (2008/06/13)
Imidazole derivatives of formula (I): wherein R 1 , R 2a , R 2b , A, V and W are as defined in the description, as inhibitors of fructose-1,6-bisphosphatase, their preparation process and their use in the prevention or treatment of diabetes, and other dis
Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase
Boger, Dale L.,Labroli, Marc A.,Marsilje, Thomas H.,Jin, Qing,Hedrick, Michael P.,Baker, Stephen J.,Shim, Jae Hoon,Benkovic, Stephen J.
, p. 1075 - 1086 (2007/10/03)
The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. (C) 2000 Elsevier Science Ltd.
