289681-47-6

Basic information

• Product Name: 2-Hydroxy-5-iodo-3-methylpyridine
• Synonyms: 2-Hydroxy-5-iodo-3-methylpyridine;5-iodo-3-methylpyridin-2-ol;5-Iodo-3-Methyl-2-pyridone;2(1H)-Pyridinone,5-iodo-3-Methyl-;5-Iodo-3-methyl-2(1H)-pyridinone;5-iodo-3-methyl-1H-pyridin-2-one
• CAS NO: 289681-47-6
• Molecular Formula: C₆H₆INO
• Molecular Weight: 235.03
• Mol File: 289681-47-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 312.3°Cat760mmHg
• Flash Point: 142.7°C
• Appearance: /
• Density: 1.94g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Hydroxy-5-iodo-3-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-5-iodo-3-methylpyridine(289681-47-6)
• EPA Substance Registry System: 2-Hydroxy-5-iodo-3-methylpyridine(289681-47-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 289681-47-6(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-5-iodo-3-methylpyridine is a chemical compound with the molecular formula C6H6INO. It is a derivative of pyridine, with a hydroxy group and an iodine atom attached to the 2 and 5 positions, respectively, and a methyl group attached to the 3 position. 2-Hydroxy-5-iodo-3-methylpyridine is commonly used as an intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. It possesses important chemical properties that make it useful for the synthesis of various biologically active compounds. Additionally, its structure and reactivity make it a valuable building block for the development of novel pharmaceuticals and agrochemicals. Overall, 2-Hydroxy-5-iodo-3-methylpyridine plays an important role in the field of organic chemistry and has potential applications in the development of new drugs and crop protection agents.

Upstream product

• 166266-19-9 2-amino-3-methyl-5-iodopyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 

Downstream Products

• 289681-53-4 2-[2-(4-nitrophenyl)ethoxy]-5-[5'-O-(4,4'-dimethoxytrityl)-1',2'-dideoxy-β-D-erythro-pentafuranozyl]-3-methylpyridine 
• 289681-50-1 ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol 
• 289681-52-3 2-[2-(4-nitrophenyl)ethoxy]-5-(1',2'-dideoxy-β-D-erythro-pentofuranosyl)-3-methylpyridine 
• 383882-58-4 2-[2-(4-nitrophenyl)ethoxy]-5-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-3-methylpyridine 
• 289681-48-7 5-iodo-3-methyl-2-[2-(4-nitrophenyl)ethoxy]pyridine 

Relevant articles and documents

Synthesis of a dA-dT base pair analogue and its effects on DNA-ligand binding

Two nucleoside derivatives containing the base analogues 3-deazaadenine and 3-methyl-2-pyridone have been prepared as analogues of dA and dT, respectively. After conversion into the appropriately protected phosphoramidites, DNA sequences were prepared with site-specifically placed analogues. When present in a duplex DNA sequence, the analogues result in the deletion of one or both of the hydrogen bonding functional groups (the N3-nitrogen of dA and the O2-carbonyl of dT) present in the minor groove. Binding by two ligands, 4′,6-diamidine-2-phenyl indole (DAPI) and Hoechst 33258 in the minor groove has been probed using a variety of DNA sequences. These sequences contain a d(GAATTC)2 core with analogue nucleosides substituted for one or more of the dA and dT residues. DAPI bound strongly to any sequence that contained both O2-carbonyls of the central two dT residues. The presence of a dc3A residue did in some cases enhance binding. With one of the central O2-carbonyls deleted, the binding was noticeably reduced, and with both absent, no significant binding could be detected. Similar although less dramatic results were observed with Hoechst 33258 binding to analogue sequences.