289711-60-0Relevant academic research and scientific papers
An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids
Abbas, Sahar,Hayes, Christopher J.
, p. 4513 - 4517 (2000)
The synthesis of a range of 5'-deoxy-5'-methylidene phosphonate- containing thymidine dimers has been achieved using a palladium-catalysed cross coupling reaction as a key step. The optimised reaction conditions comprising of palladium acetate, 1,1'-bis(diphenylphosphino)ferrocene and propylene oxide in THF were found to couple a range of H-phosphonates and vinyl bromide 3 in fair to excellent yield. (C) 2000 Elsevier Science Ltd.
