289719-40-0

Basic information

• Product Name: 1,4,7,10-Tetraazacyclododecane, 1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 289719-40-0
• Molecular Formula: C15H26N4O2S
• Molecular Weight: 326.463
• Mol File: 289719-40-0.mol

Chemical Properties

• CAS DataBase Reference: 1,4,7,10-Tetraazacyclododecane, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-Tetraazacyclododecane, 1-[(4-methylphenyl)sulfonyl]-(289719-40-0)
• EPA Substance Registry System: 1,4,7,10-Tetraazacyclododecane, 1-[(4-methylphenyl)sulfonyl]-(289719-40-0)

Safety Data

• Hazardous Substances Data: 289719-40-0(Hazardous Substances Data)

Usage

General Description

1,4,7,10-Tetraazacyclododecane, 1-[(4-methylphenyl)sulfonyl]-, also known as DOTAM, is a chemical compound used in various applications such as coordination chemistry and medical imaging. It is a macrocyclic chelating agent that forms stable complexes with metal ions, making it useful in the field of radiopharmaceuticals and MRI contrast agents. The 1-[(4-methylphenyl)sulfonyl]- group attached to the DOTAM molecule adds a sulfonamide functionality, which can be used for various chemical modifications and reactions. DOTAM and its derivatives have potential applications in molecular imaging, drug delivery systems, and as MRI contrast agents due to their ability to chelate metal ions and their favorable chemical properties.

Upstream product

• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 98-59-9 p-toluenesulfonyl chloride 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 111-40-0 3-azapentane-1,5-diamine 

Downstream Products

• 1030955-99-7 N,N',N''-trimethyl-N'''-(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane 

Relevant articles and documents

Development of a highly selective fluorescence probe for hydrogen sulfide

Hydrogen sulfide (H2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H2S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry

An improved synthesis of 1,4,7-triazacyclononanes (tacns) and 1,4,7,10-tetraazacyclododecanes (cyclens)

Reaction of tosylbis[2-(tosyloxy)ethyl]amine with ethylenediamine gives 1-tosyl-1,4,7-triazacyclononane in good yield. A similar reaction of tosylbis[2-(tosyloxy)ethyl]amine with diethylenetriamine gives 1-tosyl-1,4,7,10-tetraazacyclododecane. These tosyl

Rare-earth metal alkyl and hydride complexes stabilized by a cyclen-derived [NNNN] macrocyclic ancillary ligand

A trinuclear rare-earth metal hydride complex was synthesized from the dialkyl complex supported by a monoanionic [NNNN] macrocycle and shown to catalyze the hydrosilylation of olefins efficiently. Copyright

1,4-Bis-(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane from the direct tosylation of 1,4,7,10-tetraazacyclododecane

The reaction between 1,4,7,10-tetraazacyclododecane and 4-toluenesulphonyl chloride in triethylamine/chloroform yields both the disubstituted isomers of bis-(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane. This has been confirmed by 1H NMR

Concerning two-metal cooperativity in model phosphate hydrolysis

Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.

Regioselective synthesis of 1,7-diprotected 1,4,7,10-tetraazacyclododecane and preparation of a dialcohol dicarboxylic macrocyclic ligand

The reaction of 1,4,7,10-tetraazacyclododecane with p-toluenesulfonyl chloride in pyridine or with diethyl phosphite and CCl4 in a water/CH2Cl2 mixture yields selectively the 1,7-diprotected regioisomer.The 1,7-diprotected tetraaza cycles are interesting