289719-83-1Relevant academic research and scientific papers
A new synthetic route to β-unsubstituted β-lactones by intramolecular cyclization
Alexandre, Fran?ois-René,Legoupy, Stéphanie,Huet, Fran?ois
, p. 3921 - 3926 (2007/10/03)
When carboxylic acids β-substituted by a tert-butoxy group were treated with thionyl chloride, an intermediate acyl chloride β-substituted by a hydroxyl group was likely formed. Its subsequent intramolecular cyclization produced novel β-lactones in one step. Two enantiomerically enriched lactones could be prepared via intermediates obtained by enzymatic hydrolysis. (C) 2000 Elsevier Science Ltd.
