28988-26-3

Usage

InChI:InChI=1/C8H7NS/c1-6-4-8-7(5-9-6)2-3-10-8/h2-5H,1H3

Upstream product

• 98594-04-8 5-ethyl-2-methyl-pyridine-4-thiol 
• 61940-10-1 7-methoxy-6-methyl-4,5,6,7-tetrahydro-thieno(3,2-c)pyridine 

Relevant academic research and scientific papers

Process for the preparation of thieno(3,2-c) pyridine and derivatives thereof

This invention relates to a process for the preparation of compounds having the formula: STR1 in which R1 is H or lower alkyl and R2 is H or lower alkyl, or phenyl or benzyl optionally substituted with at least one halogen or a lower alkyl, lower alkoxy, trifluoromethyl or nitro group. According to this method, a compound of the formula: STR2 in which R1 and R2 are as defined above and R3 is H or optionally substituted alkyl or benzyl, is reacted with a derivative Hal--SO2 --R (III) in which Hal is halogen and R is optionally substituted alkyl, aryl or aralkyl, to give a derivative of the formula: STR3 in which the various symbols have the above-defined meanings, and the sulfonated derivative of the formula (IV) is heated in the presence of an acid, to give the compound of the formula (I).