289889-83-4Relevant academic research and scientific papers
B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings under Mild Aqueous Micellar Conditions
Lee, Nicholas R.,Linstadt, Roscoe T. H.,Gloisten, Danielle J.,Gallou, Fabrice,Lipshutz, Bruce H.
, p. 2902 - 2905 (2018)
Use of B-sp3-alkyl reagents for Suzuki-Miyaura couplings under aqueous micellar catalysis conditions is reported. Studies as to substrate scope, use in a four-step one-pot sequence, and reaction medium recycling exemplify the synthetic utility of this technology. OBBD (B-alkyl-9-oxa-10-borabicyclo[3.3.2]decane) derivatives are easily made and utilized for couplings under mild conditions. Comparisons were also made between OBBD and 9-BBN (B-alkyl-9-borabicyclo[3.3.1]nonane) derivatives as reaction partners.
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists
Dowd,Herrick-Davis,Egan,DuPre,Smith,Teitler,Glennon
, p. 3074 - 3084 (2007/10/03)
Phenylalkylamines such as 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB; 1a) and its corresponding iodo derivative DOI (2) are commonly used 5-HT2 serotonin agonists. Previous studies have established that the 2,5-dimethoxy substitution p
