289909-44-0Relevant academic research and scientific papers
Stereo- and Regiocontrolled Methylboration of Terminal Alkynes
Zhurakovskyi, Oleksandr,Dias, Rafael M. P.,Noble, Adam,Aggarwal, Varinder K.
supporting information, p. 3136 - 3139 (2018/05/28)
A scalable and operationally simple synthesis of trisubstituted alkenyl boronic esters has been achieved using a Zr-catalyzed carboalumination of terminal alkynes followed by in situ transmetalation with i-PrOBpin. The products are formed in good yields and with excellent regioselectivity and perfect stereoselectivity. The new procedure provides a significant improvement over the previously reported syntheses.
Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides
Wu, Zhao,Laffoon, Joshua D.,Nguyen, Trang T.,McAlpin, Jacob D.,Hull, Kami L.
supporting information, p. 1371 - 1375 (2017/01/24)
A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.
Enantioselective synthesis of quaternary carbon stereogenic centers through copper-catalyzed conjugate additions of aryl- and alkylaluminum reagents to acyclic trisubstituted enones
Dabrowski, Jennifer A.,Villaume, Matthew T.,Hoveyda, Amir H.
supporting information, p. 8156 - 8159 (2013/08/23)
Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite
