289909-45-1Relevant academic research and scientific papers
Enantioselective synthesis of quaternary carbon stereogenic centers through copper-catalyzed conjugate additions of aryl- and alkylaluminum reagents to acyclic trisubstituted enones
Dabrowski, Jennifer A.,Villaume, Matthew T.,Hoveyda, Amir H.
, p. 8156 - 8159 (2013)
Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite
Stereo- and Regiocontrolled Methylboration of Terminal Alkynes
Zhurakovskyi, Oleksandr,Dias, Rafael M. P.,Noble, Adam,Aggarwal, Varinder K.
supporting information, p. 3136 - 3139 (2018/05/28)
A scalable and operationally simple synthesis of trisubstituted alkenyl boronic esters has been achieved using a Zr-catalyzed carboalumination of terminal alkynes followed by in situ transmetalation with i-PrOBpin. The products are formed in good yields and with excellent regioselectivity and perfect stereoselectivity. The new procedure provides a significant improvement over the previously reported syntheses.
