289915-17-9Relevant academic research and scientific papers
Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists
Tilley, Jefferson,Kaplan, Gerry,Fotouhi, Nader,Wolitzky, Barry,Rowan, Karen
, p. 1163 - 1165 (2007/10/03)
Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide. (C) 2000 Elsevier Science Ltd. All rights reserved.
