28995-82-6

Usage

Uses

Used in Pharmaceutical Industry:
(Z)-2-iodo-2-phenylethenyl methyl sulfone is used as an intermediate for the synthesis of various pharmaceuticals due to its unique properties and reactivity.
Used in Agrochemical Industry:
(Z)-2-iodo-2-phenylethenyl methyl sulfone is used as an intermediate for the synthesis of various agrochemicals, contributing to its wide range of applications in this field.
Used in Organic Synthesis:
(Z)-2-iodo-2-phenylethenyl methyl sulfone is used as a reagent in organic synthesis, taking advantage of its unique properties to facilitate various chemical reactions.
Used in Biological Research:
(Z)-2-iodo-2-phenylethenyl methyl sulfone is used as a subject of study for its potential biological activities, such as anti-inflammatory, antioxidant, and anticancer properties, which could lead to the development of new therapeutic agents.

Upstream product

• 67-68-5 dimethyl sulfoxide 
• 536-74-3 phenylacetylene 
• 50695-55-1 N-hydroxylmethanesulfonamide 
• 20277-69-4 sodium methansulfinate 
• 10393-86-9 methanesulphonyl hydrazide 
• 2386-57-4 methanesulfonic acid sodium salt 

Downstream Products

• 58202-71-4 (E)-1-Methylsulfonyl-2,4-diphenylbut-1-en-3-in 
• 24378-05-0 methyl phenylethynyl sulfone 

Relevant academic research and scientific papers

I2-DMSO-H2O: A Metal-Free Combination System for the Oxidative Addition of Alkynes to Access (E)-α-Iodo-β-methylsulfonylalkenes

A simple and green reaction was discovered for iodization-methylsulfoxidation of alkynes to access (E)-α-iodo-β-methylsulfonylalkenes. This is the first report for the synthesis of iodovinyl methylsulfones by employing alkynes to react with molecular iodi

Decatungstate as Direct Hydrogen Atom Transfer Photocatalyst for SOMOphilic Alkynylation

A versatile approach for the alkynylation of a variety of aliphatic hydrogen donors, including alkanes, is reported. We used tetrabutylammonium decatungstate as photocatalyst to generate organoradicals from C-H/Si-H bonds via hydrogen atom transfer. The l

An iodine-mediated new avenue to sulfonylation employingN-hydroxy aryl sulfonamide as a sulfonylating agent

A novel and highly efficient I2/K2CO3mediated regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes withN-hydroxy sulfonamide has been developed.N-hydroxy sulfonamide has been used for the first time for the synthesis of these sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of different analogs of sulfones with various structural features.

Iodosulfonylation of Alkynes under Ultrasound Irradiation

(E)-Iodo vinylsulfones are synthesized under ultrasound irradiation using alkynes, sulfonyl hydrazides, potassium iodide and hydrogen peroxide. The key features of this protocol are the speed and efficiency of the reactions, which afford good to excellent

Synthesis of (: E)-β-iodo vinylsulfones via iodine-promoted iodosulfonylation of alkynes with sodium sulfinates in an aqueous medium at room temperature

An efficient molecular iodine-promoted method for the synthesis of (E)-β-iodo vinylsulfones using water as the solvent at room temperature has been developed. This green reaction is fast, operationally simple, environmentally benign and, especially, proceeds under very mild conditions to afford the target products with high regio- and stereoselectivity.

Synthesis of (E)-β-iodovinyl sulfones via DTBP/I2 promoted difunctionalization of alkynes with sodium benzenesulfinates

The present reaction provides a simple and convenient synthetic strategy to construct β-iodovinyl sulfones through molecular iodine and DTBP (di-tert-butyl peroxide) promoted difunctionalization of alkynes with sodium benzenesulfinates under mild and envi

Stereoselective synthesis of (E)-alkenyl sulfones from alkenes or alkynes via copper-catalyzed oxidation of sodium sulfinates

Alkenyl sulfones can be stereoselectively synthesized from alkenes or alkynes using sodium sulfinates. The reaction can be performed by a copper-catalyzed oxidation of sodium sulfinates in air. The reaction of alkenes gives (E)-alkenyl sulfones via anti addition of sulfonyl cation and elimination process. Furthermore, the employment of alkynes produces (E) β- haloalkenyl sulfones in the presence of potassium halides. Georg Thieme Verlag Stuttgart · New York.