290293-87-7Relevant academic research and scientific papers
Non-heterocyclic beta -phenyl- alpha -aminopropionic acid n-phenyl amides for treatment of neurotoxic injury
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, (2008/06/13)
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a beta -phenyl- alpha -aminopropionic acid N phenyl amide compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula wherein each of R1 and R5 is independently selected from hydrido, fluoro, chloro, bromo, methyl and ethyl; wherein R3 is selected from hydroxy, methoxy, ethoxy, methoxycarbonyloxy, ethoxycarbonyloxy, (2-methylpropoxy)carbonyloxy and (2-propenyloxy) carbonyloxy; wherein each of R6, R7 and R8 is hydrido; wherein each of R9 and R10 is independently selected from hydrido, methyl and ethyl; wherein R11 is one or more groups independently selected from hydrido, fluoro, chloro, hydroxy, methoxy, methyl and ethyl; or a tautomer or enantiomer therefor, or a pharmaceutically-acceptable salt or ester thereof.
