290294-28-9

Upstream product

• 290294-27-8 1-benzyl-3a-methyl-2,3,3a,8a-tetrahydro-1H-pyrrolo[2,3-b]indol-5-one 
• 290294-26-7 1-benzyl-5-methoxy-3a-methyl-2,3,3a,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-8-carbaldehyde 
• 100-46-9 benzylamine 
• 469-22-7 eseroline 
• 438245-98-8 C₁₉H₂₂N₂O 

Downstream Products

• 219920-81-7 (-)-N¹,N⁸-bisnorcymserine 
• 290294-30-3 N₁-benzyl-N₈-norcymserine 

Relevant academic research and scientific papers

Compound useful in the treatment or prevention of cognitive disorders associated with diabetes and associated methods

Described is the efficient synthesis of an easy to manipulate and utilize, soluble tartrate salt of a potent, reversible butyrylcholinesterase inhibitor, (?)-(3aS)-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indol-5-yl N—4′-isopropylphenylcarbamate (“

A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine

A rapid novel synthetic route to the potent reversible butyrylcholinesterase inhibitor (-)-N1,N8-bisnorcymserine (1) is reported from physostigmine (2) in a 20% total yield. Details on the formation of the imino-quinone 6 obtained in the oxidation of N1-benzylnoresermethole (4) and its conversion into N1-bisnoreseroline (7) are given. As expected, the product of this synthesis, (1), had identical biological activity to the same agent produced by total synthesis. (C) 2000 Elsevier Science Ltd.