290307-27-6

Basic information

• Product Name: (+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol
• Synonyms: (+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol
• CAS NO: 290307-27-6
• Molecular Weight: 400.22
• Mol File: 290307-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(290307-27-6)
• EPA Substance Registry System: (+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(290307-27-6)

Safety Data

• Hazardous Substances Data: 290307-27-6(Hazardous Substances Data)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 290307-39-0 3-cyclobutoxy-4-difluoromethoxy-benzaldehyde 

Downstream Products

• 290307-29-8 2-bromo-5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-pyridine 
• 1027864-06-7 3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester 
• 290307-28-7 (+/-)-4-{2-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-2-[5-(2-bromo)pyridyl]ethyl}pyridine 

Relevant articles and documents

Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFα in human whole blood, the binding affinity