290315-22-9

Upstream product

• 223676-06-0 (S)-2-(benzyloxy)-5-(tert-butyldimethylsiloxy)pentanal 
• 90-04-0 2-methoxy-phenylamine 
• 290315-09-2 (4S,5S)-5-Benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-4-(2-methoxy-phenylamino)-octan-2-one 

Downstream Products

• 1061357-71-8 3-benzyloxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 290315-14-9 tert-butyl (2S,3S)-3-(benzyloxy)-2-(3-bromo-2-oxopropyl)piperidine-1-carboxylate 
• 32434-44-9 (+)-isofebrifugine 
• 290315-13-8 1-((2S,3S)-3-Benzyloxy-piperidin-2-yl)-propan-2-one 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of febrifugine and isofebrifugine

Antimalarial alkaloids, febrifugine (1) and isofebrifugine (2), were synthesized from simple achiral starting materials using tin(II)-catalyzed catalytic asymmetric aldol reaction and lanthanide-catalyzed aqueous three- component reaction as the key steps. These unambigous total syntheses revealed that the absolute configurations of febrifugine and isofebrifugine were not (2'S, 3'R) and (2'R, 3'R) as reported previously but (2'R, 3'S) and (2'S, 3'S), respectively.