290327-96-7Relevant academic research and scientific papers
N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors
Parker, Michael F.,Barten, Donna M.,Bergstrom, Carl P.,Bronson, Joanne J.,Corsa, Jason A.,Deshpande, Milind S.,Felsenstein, Kevin M.,Guss, Valerie L.,Hansel, Steven B.,Johnson, Graham,Keavy, Daniel J.,Lau, Wai Y.,Mock, Jeremy,Prasad,Polson, Craig T.,Sloan, Charles P.,Smith, David W.,Wallace, Owen B.,Wang, Henry H.,Williams, Andrew,Zheng, Ming
, p. 4432 - 4436 (2008/02/10)
A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo γ-secretase activity.
Sulfonamide compounds and uses thereof
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Page/Page column 12, (2010/02/14)
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group incl
