290327-98-9Relevant academic research and scientific papers
Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase
Bergstrom, Carl P.,Sloan, Charles P.,Wang, Henry H.,Parker, Michael F.,Smith, David W.,Zheng, Ming,Hansel, Steven B.,Polson, Craig T.,Barber, Lauren E.,Bursuker, Isia,Guss, Valerie L.,Corsa, Jason A.,Barten, Donna M.,Felsenstein, Kevin M.,Roberts, Susan B.
, p. 175 - 178 (2008/09/17)
The synthesis and γ-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11-47) are described. Inhibition of brain Aβ in transgenic mice was demonstrated by two of these compounds (23 and 44).
