290332-71-7Relevant academic research and scientific papers
Meyers' bicyclic lactam formation under mild and highly stereoselective conditions
Penhoat, Ma?l,Leleu, Stephane,Dupas, Georges,Papamica?l, Cyril,Marsais, Francis,Levacher, Vincent
, p. 8385 - 8389 (2005)
New and mild conditions to prepare chiral bicyclic lactams in high yields and high diastereoselectivities are reported herein. This approach based on the activation of the carboxylic acid by means of Mukaiyama's reagent is an excellent alternative to Meye
Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: Observation of stereoelectronic effects
Chen, Ming-De,He, Ming-Zhu,Zhou, Xiang,Huang, Li-Qiang,Ruan, Yuan-Ping,Huang, Pei-Qiang
, p. 1335 - 1344 (2007/10/03)
Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin- 1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions.
Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives
Allin, Steven M.,Northfield, Christopher J.,Page, Michael I.,Slawin, Alexandra M.Z.
, p. 1715 - 1721 (2007/10/03)
New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylglycinol
