290332-97-7

Basic information

• Product Name: ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE
• Synonyms: ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE;Ethyl 4-methoxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylate ,99%;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-Methoxy-, ethyl ester;Ethyl 4-methoxy-7-azaindole-2-carboxylate
• CAS NO: 290332-97-7
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.22
• Mol File: 290332-97-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.269g/cm³
• Refractive Index: 1.604
• CAS DataBase Reference: ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE(290332-97-7)
• EPA Substance Registry System: ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE(290332-97-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 290332-97-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

InChI:InChI=1/C11H12N2O3/c1-3-16-11(14)8-6-7-9(15-2)4-5-12-10(7)13-8/h4-6H,3H2,1-2H3,(H,12,13)

Upstream product

• 620-08-6 4-methoxypyridine 
• 82257-15-6 4-methoxynicotinaldehyde 
• 290332-96-6 ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate 

Downstream Products

• 290332-99-9 2-hydroxymethyl-4-methoxypyrrolo[2,3-b]pyridine 
• 290333-04-9 C₃₇H₄₂N₃O₄PSi 
• 492438-96-7 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid 
• 492438-83-2 5-acetyl-9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492439-25-5 7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol 
• 492439-03-9 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol 
• 492438-84-3 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid 
• 492439-23-3 [7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine 
• 492438-89-8 [5-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine 
• 492438-80-9 5-acetyl-9-benzylamino-4-methoxy-6,7-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492438-69-4 9-benzylamino-7-ethoxycarbonyl-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492438-82-1 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492439-09-5 9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid 
• 492438-78-5 9-benzylamino-5-bromo-4-methoxy-6,7-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 

Relevant articles and documents

Synthesis of some fused β-carbolines including the first example of the pyrrolo[3,2-c]-β-carboline system

Condensation of 1-methyl-β-carboline-3-carbaldehyde with ethyl azidoacetate and subsequent thermolysis of the resulting azidopropenoate was used to [c] annulate a pyrrole ring onto the β-carboline moiety, thus producing the first example of the pyrrolo[3,

PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

Carbodiimide-mediated preparation of the tricyclic pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine ring system and its application to the synthesis of the potent antitumoral marine alkaloid variolin B and analog

A total synthesis of the marine alkaloid variolin B has been completed in 13 steps in an overall yield of 6.5% from 3-formyl-4-methoxypyridine. Our approach is based on the sequential formation of the 7-azaindole ring, the tricyclic pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine ring system, and finally installation of the 2-aminopyrimidine ring at C5. The required 7-azaindole ring appropriately substituted is formed by a modified indole synthesis involving a nitrene insertion process (two steps). Formation of the annelated pyrimidine ring is achieved by two routes both involving a carbodiimide-mediated cyclization process, which allow incorporation of the amine functionality at C9 of the core tricyclic (six steps). Installation of the northeast 2-aminopyrimidine ring at C5 is performed using the Bredereck protocol (three steps). Ultimate, thermal decarboxylation with concomitant O-methyl deprotection and further N-benzyl deprotection by the action of triflic acid completed the synthesis of the target natural product variolin B.