2904-59-8

Upstream product

• 51903-38-9 2,4,6-trimethoxybenzaldehyde oxime 
• 2571-54-2 2,4,6-trimethoxybenzonitrile 
• 621-23-8 1,2,3-trimethoxybenzene 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 

Downstream Products

• 51983-76-7 6t,7t-dichloro-4-(2,4,6-trimethoxy-phenyl)-(1rH,5cH)-2-oxa-3-aza-bicyclo[3.2.0]hept-3-ene 
• 51983-76-7 6c,7c-dichloro-4-(2,4,6-trimethoxy-phenyl)-(1rH,5cH)-2-oxa-3-aza-bicyclo[3.2.0]hept-3-ene 
• 56754-43-9 N-tert-Butyl-N,N'-dihydroxy-2,4,6-trimethoxy-benzamidine 
• 121561-92-0 9-[3-(2,4,6-Trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-9H-carbazole 
• 128103-51-5 (4S,5S)-5-p-Tolyl-3-(2,4,6-trimethoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester 
• 128127-17-3 (4S,5S)-5-Phenyl-3-(2,4,6-trimethoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid tert-butyl ester 
• 101028-90-4 5-tert-Butyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxazaphosphol 
• 143593-33-3 4,5-Dimethyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 143593-39-9 4-Methyl-5-phenyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 143593-41-3 4-Isopropyl-5-phenyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 143593-37-7 4,5-Diisopropyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 143593-43-5 5-Methyl-4-phenyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 143593-35-5 5-Ethyl-4-isopropyl-3-(2,4,6-trimethoxyphenyl)-1,2,4-oxadiazolium Hexachloroantimonate 
• 51675-22-0 2,4,6-trimethoxyphenyl isothiocyanate 

Relevant academic research and scientific papers

Synthesis, antimicrobial and antioxidant activities of 2-isoxazoline derivatives

A series of derivatives of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(40phenyl)thiosemicarbazide (9) and of trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (10a–c) were synthesized

Trifluoromethanesulfonyloxy-group-directed regioselective (3 + 2) cycloadditions of benzynes for the synthesis of functionalized benzo-fused heterocycles

Highly regioselective (3 + 2) cycloadditions of (trifluoromethanesulfonyloxy)benzynes [(triflyloxy)benzynes] with 1,3-dipoles followed by cross-coupling reactions provided multisubstituted benzo-fused heterocycles. The triflyloxy group at the 3-position of benzynes, and even that at the remote 4-position, greatly affected the regiocontrol of the cycloaddition. These groups also served to install other substituents at their ipso-positions.

Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: Reversal cyclooxygenase-2 selectivity by sulfonamide group removal

3,4-Diarylisoxazole analogues of valdecoxib [4-(5-methyl-3-phenylisoxazol- 4-yl)-benzensulfonamide], a selective cyclooxygenase-2 (COX-2) inhibitor, were synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides to the enolate ion of phenylacetone regioselectively prepared in situ with lithium diisopropylamide at 0 °C. The corresponding 3-aryl-5-methyl-4-phenyl- isoxazoles were easily generated by a dehydration/aromatization reaction under basic conditions of 3-aryl-5-hydroxy-5-methyl-4-phenyl-2-isoxazolines and further transformed into their benzenesulfonamide derivatives. The biochemical COX-1/COX-2 selectivity was evaluated in vitro by using the human whole blood assays of COX isozyme activity. Three compounds not bearing the sulfonamide group present in valdecoxib were selective COX-1 inhibitors.

Enthalpies of combustion of 2,4,6-trimethylbenzonitrile, 2,4,6-trimethylbenzonitrile N-oxide, 2,6-dimethylbenzonitrile, 2,4,6-trimethoxybenzonitrile, and 2,4,6-trimethoxybenzonitrile N-oxide: the dissociation ethalpies of the (N-O) bonds

The standard (pdeg = 0.1 MPa) molar enthalpies of combustion at 298.15 K were measured by static-bomb calorimetry and the standard molar enthalpies of sublimation at 298.15 K were measured by microcalorimetry for the following aromatic nitriles and aromatic nitrile N-oxides: .From the standard molar enthalpies of formation of the gaseous compounds, the molar dissociation enthalpies of the (N-O) bonds were derived: D(N-O)/(kJ*mol-1): trimethylbenzonitrile N-oxide, (222.2 +/- 4.6); trimethoxybenzonitrile N-oxide, (232.8 +/- 3.8).

1,3-Dipolar Cycloaddition of Nitrile Oxides to N-Vinylcarbazole: Regioselective Formation of 5-(9-Carbazolyl)-Δ2-Isoxazolines

Aryl substituted nitrile oxides undergo 3 + 2 cycloaddition to N-vinylcarbazole to afford only one regioisomer, i.e., 3-aryl sustituted 5-(9-carbazolyl)-Δ2-isoxazolines III in good yield.