29052-39-9Relevant academic research and scientific papers
Purines XIV. [1]. Reactivity of 8-Bromo-3,9-dimethylxanthine Towards Some Nucleophilic Reagents
Youssef, Shaker,Pfleiderer, Wolfgang
, p. 949 - 954 (2007/10/03)
The reactivity of 8-bromo-3,9-dimethylxanthine (6) towards a variety of nucleophilic reagents has been investigated. Nucleophilic displacements take place easily with aliphatic mercaptans and aliphatic alcohols, whereas aliphatic amines required more severe conditions. Prolonged heating of 6 with amines causes a new type of rearrangement from 3,9- to 3,7-dimethylxanthines due to a 1,3-sigmatropic shift of the N(9)-methyl group.
