29067-94-5Relevant academic research and scientific papers
Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives
Vidal, Matías,García-Arriagada, Macarena,Rezende, Marcos Caroli,Domínguez, Moisés
, p. 4246 - 4252 (2016/11/26)
Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.
