290810-34-3

Upstream product

• 210292-02-7 [(4S,5S)-5-(4-Methylsulfanyl-phenyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-methanol 
• 74-88-4 methyl iodide 

Downstream Products

• 850449-37-5 (4S,5S,R_S)-4-methoxymethyl-5-(4-methylsulfinylphenyl)-2-phenyl-4,5-dihydro-1,3-oxazole 

Relevant academic research and scientific papers

Enantioselective modification of the Pomeranz-Fritsch-Bobbitt synthesis of tetrahydroisoquinoline alkaloids synthesis of (-)-salsolidine and (-)-carnegine

(-)-Salsolidine 7 and (-)-carnegine 8 were prepared in 46 and 36% e.e., respectively, by enantioselective addition of methyllithium to the Pomeranz-Fritsch imine 13 in the presence of ligands 9-12, followed by acid-catalyzed cyclization and hydrogenolysis