290832-41-6

Upstream product

• 830-96-6 Indole-3-propionic acid 
• 120-72-9 indole 
• 95226-89-4 1-[3-(1H-indol-3-yl)-1-oxopropyl]-4-(2-methoxyphenyl)piperazine 

Relevant academic research and scientific papers

2-aryl indole derivative as antagonists of tachykinins

The present invention relates to compounds of the formula (I): wherein R1a, R1b, R2, R3, R4, R5, X and n are defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis and postherpetic neuralgia.

2-Aryl indole NK1 receptor antagonists: Optimisation of indole substitution

The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the human neurokinin-1 (hNK1) receptor are reported, concentrating on optimisation of the indole substitution.