290834-64-9

Upstream product

• 1478-53-1 Diethyl difluoromethylphosphonate 
• 290834-62-7 [((2S,3R,4R,5S)-1-Allyl-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-difluoro-methyl]-phosphonic acid diethyl ester 

Downstream Products

• 290834-65-0 {[(2S,3R,4R,5S)-3,4-Bis-benzyloxy-5-benzyloxymethyl-1-(2-oxo-ethyl)-pyrrolidin-2-yl]-difluoro-methyl}-phosphonic acid diethyl ester 
• 290834-66-1 ({(2S,3R,4R,5S)-1-[2-((2S,3S,4S,5R,6S)-5-Acetylamino-4-hydroxy-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3-ylamino)-ethyl]-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl}-difluoro-methyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of new (difluoromethylphosphono)azadisaccharides designed as bisubstrate analogue inhibitors for GlcNAc:β-1,4 glycosyltransferases

We report here the design, synthesis and antifungal evaluation of a new model of bisubstrate analogue inhibitor for glycosyltransferases. The synthetic strategy relies on the reductive amination between the aldehyde derived from an N-allylphosphono-pyrrolidine and an aminosugar. (C) 2000 Elsevier Science Ltd. All rights reserved.