29102-72-5 Usage
Description
1-(3-bromopropoxy)-2,4,5-trichlorobenzene is a compound belonging to the trichlorobenzene family, characterized by a benzene ring with three chlorine atoms and a bromine atom. It also features a propoxy group, which is a branch of three carbon atoms attached to an oxygen atom. This unique molecular structure endows it with specific chemical properties that make it potentially useful for a variety of applications in different industries.
Uses
Used in Organic Synthesis:
1-(3-bromopropoxy)-2,4,5-trichlorobenzene is used as an intermediate in organic synthesis for its unique molecular structure that can be further modified or reacted to produce a range of other compounds. Its presence of chlorine, bromine, and oxygen atoms allows for versatile chemical reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Reactions:
In the chemical industry, 1-(3-bromopropoxy)-2,4,5-trichlorobenzene is used as a reactant in various chemical reactions due to its reactive functional groups. The chlorine and bromine atoms can be replaced by other functional groups through substitution reactions, while the propoxy group can participate in etherification or esterification reactions, leading to the formation of new compounds with different properties and applications.
Used in Material Science:
1-(3-bromopropoxy)-2,4,5-trichlorobenzene is also utilized in material science as a component in the development of novel materials with specific properties. Its unique structure can contribute to the formation of polymers with tailored characteristics, such as improved thermal stability, chemical resistance, or mechanical strength. Additionally, it may be used in the creation of advanced coatings, adhesives, or elastomers that require specific chemical and physical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 29102-72-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,1,0 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 29102-72:
(7*2)+(6*9)+(5*1)+(4*0)+(3*2)+(2*7)+(1*2)=95
95 % 10 = 5
So 29102-72-5 is a valid CAS Registry Number.
29102-72-5Relevant articles and documents
Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors
Zhou, Xiaotian,Lin, Kuaile,Ma, Xiang,Chui, Wai-Keung,Zhou, Weicheng
, p. 1279 - 1288 (2016/11/29)
A novel series of dihydro-1,3,5-triazine derivatives bearing a heteroatom spiro-ring were designed and synthesized on the basis of molecular flexible docking work, and their biological activities were evaluated. Compounds A2, A5, B1 and B3 showed potent human dihydrofolate reductase (hDHFR) inhibitory activity with IC50values of 7.46 nM, 3.72 nM, 6.46 nM, 4.08 nM, versus reference drug methotrexate (MTX). From the molecular docking result we concluded that the conformation space generated by deformation of the flexible residue Phe31 is favorable for the binding of the spiro-ring, and inserting heteroatom into spiro ring might increase the binding affinity. There were 24 compounds with broadspectrum antiproliferative activity against several tumor cell lines (HCT116, A549, HL-60, HepG2 and MDA-MB-231) with IC50values ranging from 0.79 to 0.001 μM. The antitumor activity in?vivo of compound A2 was determined in a human alveolar basal epithelial cell line A549 xenograft model. This study offered novel anticancer agents with high inhibitory activity that target hDHFR and have a binding mode of the novel molecular scaffold with hDHFR. This provides potent support for further development of novel hDHFR inhibitors.
Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials
Jensen,Ager,Bliss,Canfield,Kotecka,Rieckmann,Terpinski,Jacobus
, p. 3925 - 3931 (2007/10/03)
A total of 34 analogues of the biguanide PS-15 (5s), a prodrug of the diaminotriazine WR-99210 (8s), have been prepared. Several of them, such as 5b (PS-33) and 5m (PS-26), maintain or exceed the in vivo activity of PS-15 while not requiring the use of highly regulated starting materials. The putative diaminotriazine metabolites of these new analogues (compounds 8) have also been prepared and shown to maintain the activity against resistant P. falciparum strains. The structure-activity relationships of biguanides 5 and putative metabolites 8 are discussed.
Alpha-chloro-delta-aryloxyvaleric acids.
WALKER
, p. 396 - 398 (2007/10/11)
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