29113-41-5 Usage
Uses
Used in Pharmaceutical Industry:
5-butyl-6-methyl-2-thiouracil is used as an antithyroid drug for the treatment of hyperthyroidism. It is effective in managing symptoms such as weight loss, rapid heart rate, and heat intolerance, which are commonly associated with an overactive thyroid. The medication works by inhibiting the production of thyroid hormones, thus helping to regulate thyroid function and improve the overall health of individuals suffering from hyperthyroidism.
Used in Endocrinology:
In the field of endocrinology, 5-butyl-6-methyl-2-thiouracil is utilized as a therapeutic agent for the management of hyperthyroidism. It is particularly beneficial for patients who experience an overproduction of thyroid hormones, leading to various symptoms that can negatively impact their quality of life. By inhibiting the synthesis of these hormones, thiamazole helps to restore normal thyroid function and alleviate the associated symptoms.
Used in Drug Development:
5-butyl-6-methyl-2-thiouracil serves as a valuable compound in the development of new medications for the treatment of thyroid disorders. Its mechanism of action in inhibiting thyroid hormone production provides a foundation for the creation of novel therapeutic agents that can target and regulate thyroid function more effectively. This can lead to the discovery of more potent and safer drugs for the management of hyperthyroidism and other related conditions.
Used in Research:
In scientific research, 5-butyl-6-methyl-2-thiouracil is employed as a key compound for studying the pathophysiology of hyperthyroidism and the mechanisms underlying thyroid hormone production. By investigating the effects of thiamazole on thyroid function, researchers can gain a deeper understanding of the molecular processes involved in thyroid disorders and identify potential targets for the development of new treatments.
Used in Patient Care:
For patients diagnosed with hyperthyroidism, 5-butyl-6-methyl-2-thiouracil is used as a medication to alleviate the symptoms and regulate thyroid hormone levels. It is an essential component of the treatment plan for individuals suffering from this condition, helping to improve their overall health and well-being by managing the symptoms and reducing the risk of complications associated with an overactive thyroid.
Check Digit Verification of cas no
The CAS Registry Mumber 29113-41-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,1,1 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 29113-41:
(7*2)+(6*9)+(5*1)+(4*1)+(3*3)+(2*4)+(1*1)=95
95 % 10 = 5
So 29113-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N2OS/c1-3-4-5-7-6(2)10-9(13)11-8(7)12/h3-5H2,1-2H3,(H2,10,11,12,13)
29113-41-5Relevant academic research and scientific papers
Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1
Piechowicz, Katarzyna A.,Truong, Eric C.,Javed, Kashif M.,Chaney, Rachelle R.,Wu, Johnny Y.,Phuan, Puay W.,Verkman, Alan S.,Anderson, Marc O.
, p. 1362 - 1368 (2016/10/09)
Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl? channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 μM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ～1 μM for inhibition of TMEM16A chloride conductance.
REACTIONS OF ETHYL 2-ALKYL-3-OXOBUTANOATE WITH THIOUREA AND METHYLTHIOUREA
Kavalek, Jaromir,Machacek, Vladimir,Sterba, Vojeslav
, p. 1872 - 1877 (2007/10/02)
The reaction of ethyl-3-oxobutanoate with N-methylthiourea in alkoxide medium gives a mixture (1:20) of 1,6-dimethyl-2-thiouracil and 3,6-dimethyl-2-thiouracil: the latter isomer has been isolated from the mixture and the former isomer has been prepared by independent synthesis.Dissociation constants of ethyl 2-alkyl-3-oxobutanoates (alkyl = methyl, butyl or isopropyl) have been measured in methanol.Reaction of these esters with thiourea and N-methylthiourea gives the corresponding alkyl derivatives of 6-methyl-2-thiouracil.Kinetics of these reactions have been measured in methoxide medium.Effects of the alkyl groups on the reaction rates have been investigated, and a reaction mechanism is suggested.
